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KMID : 1007520130220061725
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Food Science and Biotechnology
2013 Volume.22 No. 6 p.1725 ~ p.1728
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Antibacterial Activity of a Novel Flavonoid, 7-O-Butyl Naringenin, against Methicillin-Resistant Staphylococcus aureus (MRSA)
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Lee Kyoung-Ah
Moon Sun-Hee
Lee Joo-Yeon
Kim Kee-Tae
Park Yong-Sun
Paik Hyun-Dong
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Abstract
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The objective of this study was to evaluate the antibacterial activity of a novel flavonoid, 7-O-butyl naringenin, as well as natural flavonoids (quercetin, naringenin) against methicillin-resistant Staphylococcus aureus (MRSA). 7-O-butyl naringenin showed great anti- MRSA, with a MIC (minimum inhibitory concentration) value of 0.625 mM. The number of cells treated with 25 μM 7-O-butyl naringenin was reduced by 5.2 log CFU/ mL compared with the control (DMSO). The result indicated that 7-O-butyl naringenin was more effective than the two natural flavonoids against MRSA, and may have potential as a novel therapeutic agent for MRSA infections.
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KEYWORD
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7-O-butyl naringenin, MRSA, antibacterial activity, flavonoid
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